Archive for August, 2014

Iron Speciation in Beans (Phaseolus vulgaris) Biofortified by Common Breeding

Hoppler M, Egli I, Petry N, Gille D, Zeder C, Walczyk T, Blair MW, and Hurrell RF.

August 2014 – Journal of Food Science

With the aim of evaluating the potential of ferritin iron in plant breeding, we used species-specific isotope dilution mass spectrometry to quantify ferritin iron in bean varieties with a wide range of total iron content. Zinc, phytic acid, and polyphenols were also measured. Total iron concentration in 21 bean varieties ranged from 32 to 115 ppm and was positively correlated with concentrations of zinc (P = 0.001) and nonferritin bound iron (P < 0.001). Ferritin iron ranged from 13% to 35% of total iron and increased only slightly in high iron beans (P = 0.007). Concentrations of nonferritin bound iron and phytic acid were correlated (P = 0.001), although phytic acid:iron molar ratio decreased with increasing iron concentration (P = 0.003). Most iron in high iron beans was present as nonferritin bound iron, which confirms our earlier finding showing that ferritin iron in beans was lower than previously published. As the range of ferritin iron content in beans is relatively narrow, there is less opportunity for breeders to breed for high ferritin. The relevance of these findings to the extent of iron absorption depends on resolving the question of whether ferritin iron is absorbed or not to a greater extent than nonferritin bound iron.

Iodine biomarkers: a new interactive web interface

Raghavan R, Rohner F, Raiten DJ

August 2014 – IDD Newsletter

The Biomarkers of Nutrition for Development (BOND) project began in 2010 to improve data on micronutrient deficiencies and to facilitate the assessments of micronutrient deficiencies globally. One of the important objectives of the BOND project is to translate the existing evidence from expert panels to the wider audience through the BOND website. In an effort to disseminate information to organizations and professionals addressing iodine deficiency, BOND recently released the Iodine Query Based System – an interactive tool that advises users on the most appropriate biomarkers depending on their specific needs. In addition to recommending an iodine biomarker, the QBS informs users of lab methods and cut-off values for a given biomarker. In the future, BOND will launch similar query systems for folate, zinc, iron, vitamin A, and vitamin B12.

Biomarkers of Nutrition for Development—Iodine Review

Rohner F, Zimmermann M, Jooste P, Pandav C, Caldwell K, Raghavan R, Raiten DJ.

August 2014 – Journal of Nutrition

In phase I of the Biomarkers of Nutrition for Development (BOND) project, 6 nutrients (iodine, vitamin A, iron, zinc, folate, and vitamin B-12) were selected for their high public health importance because they typify the challenges faced by users in the selection, use, and interpretation of biomarkers. For each nutrient,an expert panel was constituted and charged with the development of a comprehensive review covering the respective nutrients biology, existing biomarkers, and specific issues of use with particular reference to the needs of the individual user groups. This review represents the first in the series of reviews and covers all relevant aspects of iodine biology and biomarkers. The article is organized to provide the reader with a full appreciation of iodines background history as a public health issue, its biology, and an overview of available biomarkers and specific considerations for the use and interpretation of iodine biomarkers across a range of clinical and population-based uses. The review also includes a detailed research agenda to address priority gaps in our understanding of iodine biology and assessment.