Archive for September, 2015

Comparative Validation of Five Quantitative Rapid Test Kits for the Analysis of Salt Iodine Content: Laboratory Performance, User- and Field-Friendliness

Rohner F, Kangambèga MO, Khan N, Kargougou R, Garnier D, Sanou I, Ouaro BD, Petry N, Wirth JP, & Jooste P.

September 2015 – PLOS ONE

To render national salt iodization programs sustainable and ensure adequate iodization levels, simple methods to quantitatively assess whether salt is adequately iodized are required. Several methods claim to be simple and reliable, and are available on the market or are in development. This work has validated the currently available quantitative rapid test kits (quantRTK) in a comparative manner for both their laboratory performance and ease of use in field settings. Laboratory performance parameters (linearity, detection and quantification limit, intra- and inter-assay imprecision) were conducted on 5 quantRTK. We assessed inter-operator imprecision using salt of different quality along with the comparison of 59 salt samples from across the globe; measurements were made both in a laboratory and a field setting by technicians and non-technicians. Most of the devices showed acceptable laboratory performance, but for some of the devices, use by non-technicians revealed poorer performance when working in a routine manner. Of the quantRTK tested, the iCheck1 and I-Reader1 showed most consistent performance and ease of use, and a newly developed paper-based method (saltPAD) holds promise if further developed.

Literature review and meta-analysis: The potential of biofortification to reduce malnutrition during the 1,000 day window

Project Completed

During its new phase of operations (2014-2018), HarvestPlus aims to scale up biofortification programs and establish new scientific evidence. Specifically, HarvestPlus seeks to extend its proof of concept from a single biofortified crop to a multiple-biofortified food basket approach. HarvestPlus is also expanding its programs to pregnant women and children 0-24 months of age to improve nutrition during the “1000-day window”. To better understand the potential impact of biofortified foods on these new target groups, GroundWork is conducting a comprehensive review and meta-analysis of single and multiple micronutrient supplementation and fortification interventions on birth outcomes, growth, anemia and micronutrient status among children of less than two years of age.