Archive for December, 2019

Deworming children for soil-transmitted helminths in low and middle-income countries: systematic review and individual participant data network meta-analysis

Welch VA, Hossain A, Ghogomu E, Riddle A, Cousens S, Gaffey M, Arora P, Black R, Bundy D, Castro MC, Chen L, Dewidar O, Elliott A,Friis H, Hollingsworth TD, Horton S, King CH, Thi HL, Liu C, Rohner F, Rousham EK, Salam R, Sartono E, Steinmann P, Supali T, Tugwell P, Webb E, Wieringa F, Winnichagoon P, Yazdanbakhsh M, Bhutta ZA, Wells GA

December 2019 – Journal of Development Effectiveness

Intestinal parasites affect millions of children globally. We aimed to assess effects of deworming children on nutritional and cognitive outcomes across potential effect modifiers using individual participant data (IPD). We searched multiple databases to 27 March 2018, grey literature, and other sources. We included randomised and quasi randomised trials of deworming compared to placebo or other nutritional interventions with data on baseline infection. We used a random-effects network meta-analysis with IPD and assessed overall quality, following a pre-specified protocol. We received IPD from 19 trials of STH deworming. Overall risk of bias was low. There were no statistically significant subgroup effects across age, sex, nutritional status or infection intensity for each type of STH. These analyses showed that children with moderate or heavy intensity infections, deworming for STH may increase weight gain (very low certainty). The added value of this review is an exploration of effects on growth and cognition in children with moderate to heavy infections as well as replicating prior systematic review results of small effects at the population level. Policy implications are that complementary public health strategies need to be assessed and considered to achieve growth and cognition benefits for children in helminth endemic areas.

Mass deworming for improving health and cognition of children in endemic helminth areas: A systematic review and individual participant data network meta‐analysis

Welch VA, Ghogomu E, Hossain A, Riddle A, Gaffey M, Arora P, Dewidar O, Salam R, Cousens S, Black R, Hollingsworth TD, Horton S, Tugwell P, Bundy D, Castro MC, Elliott A, Friis H, Le HT, Liu C, Rousham EK, Rohner F, King C, Sartono E, Supali T, Steinmann P, Webb E, Wieringa F, Winnichagoon P, Yazdanbakhsh M, Bhutta YA, Wells G

November 2019 – Campbell Systematic Reviews

Soil transmitted (or intestinal) helminths and schistosomes affect millions of children worldwide. We used individual participant data network meta‐analysis (NMA) to explore the effects of different types and frequency of deworming drugs on anaemia, cognition and growth across potential effect modifiers. Our study included randomised and quasirandomised deworming trials in children for deworming compared to placebo or other interventions with data on baseline infection. The covariates were: age, sex, weight, height, haemoglobin and infection intensity. The effect estimate chosen was the mean difference for the continuous outcome of interest. We received data from 19 randomized controlled trials with 31,945 participants. Overall risk of bias was low. There were no statistically significant subgroup effects across any of the potential effect modifiers. However, analyses showed that there may be greater effects on weight for moderate to heavily infected children (very low certainty evidence). This analysis reinforces the case against mass deworming at a population‐level, finding little effect on nutritional status or cognition. However, children with heavier intensity infections may benefit more. We urge the global community to adopt calls to make data available in open repositories to facilitate individual participant data analyses such as this, which aim to assess effects for the most vulnerable individuals.

Development of methods to measure the coverage of biofortified foods – Rwanda pilot study

Project Ongoing

In collaboration with the Global Alliance for Improved Nutrition (GAIN), Sagaci Research, and the University of Rwanda, GroundWork is developing and testing methods for assessing the coverage and intake of biofortified foods. This includes development of data collection tools for market vendor interview, focus group discussions, and household-based interviews. These tools have been tested and refined in Rwanda’s Musanze district where both high-iron beans and orange-fleshed sweet potatoes have been marketed. With input from GAIN, HarvestPlus, and the International Potato Center (CIP), GroundWork is leading the development of the tools, management of the field work, data analysis, and reporting.